WEDNESDAY, September 13, 2017
International Cultural Centre; 25 Main Market Square
The registration desk is located at the International Cultural Centre. Registration will start at 10:00. The registration desk will remain open for the duration of the Symposium.
13:00 – 13:15 Welcome
13:15 – 14:05 Keynote presentation
Mikio Furuse (National Institute for Physiological Sciences, Japan): Molecular basis of paracellular diffusion barrier
Session 1. Junctional complexes of the brain barriers – beyond barrier regulation
Chairs: Malgorzata Burek (University of Würzburg, Germany) and Ingolf Blasig (Leibniz-Institut für Molekulare Pharmakologie, Germany)
14:05 – 14:35
Ingolf Blasig (Leibniz-Institut für Molekulare Pharmakologie, Germany): BBB – far more than claudin-5
14:35 – 14:55
Joan Abbott (King’s College London, UK): The BBB PPP – puzzle of the paracellular pathway
Coffee break 14:55 – 15:10
15:10 – 15:30
Eliseo Eugenin (Rutgers Medical School, USA): Novel cellular communication systems in HIV induced neuroinflammation and toxicity
15:30 – 15:50
Malgorzata Burek (University of Würzburg, Germany): Protocadherins at the blood-brain barrier
15:50 – 16:10
Maria Deli (Institute of Biophysics Biological Research Center, Hungarian Academy of Sciences, Hungary): Pericytes and BBB permeability- a co-culture model perspective
16:10 – 16:25
Luca Marchetti (University of Bern, Switzerland): Cellular and molecular mechanisms directing the pathway of Th1 versus Th17 T-cell diapedesis across the blood-brain barrier
16:25 – 16:40
Rainer F. Haseloff (Charité – Universitätsmedizin, Germany): Crossing cellular barriers by a tricellulin-derived peptide
16:40 – 16:55
David A. Antonetti (The University of Michigan, USA): Inhibiting Occludin Ser490 Phosphorylation Prevents Intracerebral Hemorrhage in Stroke
Coffee break 16:55 – 17:15
Session 2. Pathology of the brain barriers – various aspects
Chairs: Hazel Jones (Fluids and Barriers of the CNS; King’s College London, UK) and Aleksandra Szczepkowska (Institute of Animal Reproduction and Food Research of Polish Academy of Science)
17:15 – 17:30
Claus U. Pietrzik (University Medical Center of the Johannes Gutenberg – University Mainz, Germany): Clearance mechanisms of amylogenic proteins across the blood brain barrier
17:30 – 17:45
Fabien Gosselet (University Artois, France): Down-regulation of ABCA7 at the BBB level impacts cholesterol and Aβ peptide exchanges
17:45 – 18:00
Nienke M. de Wit (VU University Medical Center, the Netherlands): Possible different roles for LXRα and LXRβ in regulating blood-brain barrier integrity
18:00 – 18:15
István A. Krizbai (Hungarian Academy of Sciences, Hungary): Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes
18:15 – 18:30
Winfried Neuhaus (Austrian Institute of Technology GmbH, Austria): The blood-brain barrier is altered during Rett Syndrome: Implications for Rett-therapeutics
18:30 – 18:45
Anette H. H. van Boxel-Dezaire (Cleveland Clinic Foundation, USA): IFN-γ, IL-17A, and zonulin can all within 3 hours enhance permeability of the blood-brain and intestinal barrier in vitro; is a similar signal transduction pathway involved in very rapidly opening of these barriers?
18:45 – 19:00
Christina Simoglou Karali (University of Oxford, Oxford, UK): The impact of brain metastasis on endothelial cell function
19:30 – 21:00
Welcome reception (International Cultural Centre; 25 Main Market Squere)
THURSDAY; September 14, 2017
International Cultural Centre; 25 Main Market Square
08:30 – 09:20 Keynote presentation
Michal Schwartz (Weizmann Institute of Science, Israel): Harnessing systemic immunity to combat Alzheimer’s disease
Session 3. Blood-brain barrier and HIV reservoirs in the CNS – formation and eradication
(sponsored by the National Institutes of Health/National Institute of Mental Health; NIH/NIMH)
Chairs: Jeymohan Joseph (NIH/NIMH, USA) and Joan Berman (Albert Einstein College of Medicine, USA)
09:20 – 09:25
Jeymohan Joseph (NIH/NIMH, USA): Opening remarks
09:25 – 09:45
Joan Berman (Albert Einstein College of Medicine, USA): Mechanisms of CNS viral seeding by transmigration of HIV+CD14+CD16+ monocytes across the blood brain barrier: establishment and reseeding of viral reservoirs contributing to HAND
09:45 – 10:05
Kenneth Williams (Boston College, USA): Modulation of perivascular macrophage traffic into and out of the CNS, targeting CNS macrophage reservoirs of HIV
Coffee break 10:05 – 10:20
10:20 – 10:40
Michal Toborek (University of Miami, USA): Regulatory impact of occludin on the formation of HIV reservoirs in neural progenitor cells and brain pericytes
10:40 – 11:00
Carmela Pinnetti (National Institute for the Infectious Disease “L. Spallanzani”, Italy): Blood brain barrier function and the risk of CSF HIV escape
11:00 – 11:20
C. Sabrina Tan (Harvard Medical School, USA): Reaching the CNS with neutralizing antibodies
11:20 – 12:30 Lunch
Session 4. Pathology of the brain barriers – experimental aspects
Chairs: Joan Abbott(King’s College London, UK) and Magdalena Zielińska (Mossakowski Medical Research Centre, Polish Academy of Sciences, Poland)
12:30 – 12:50
Richard F. Keep (University of Michigan, USA): Endogenous mechanisms involved in barrier protection
12:50 – 13:10
Yuri Persidsky (Temple University, USA): Blood brain barrier dysfunction in diabetes mellitus correlates with cognitive deficits
13:10 – 13:30
Shilpa Buch (University of Nebraska Medical Center, USA):A novel role of pericytes in cocaine-mediated neuroinflammation
13:30 – 13:50
Elga de Vries (VU University Medical Center, The Netherlands): Molecular control of the brain barriers in multiple sclerosis
13:50 – 14:10
Martin Lauritzen (University of Copenhagen, Denmark): 2-photon microscopy of cerebral capillaries
Coffee break 14:10 – 14:25
Session 5. Pathology of the brain barriers – clinical aspects
Chairs: Maciej Mrugala (Mayo Clinic, USA) and Anuska Andjelkovic-Zochowski (University of Michigan, USA)
14:25 – 14:45
Ofer Prager (Ben-Gurion University of the Negev, Israel): Neurovascular interactions under BBB dysfunction
14:45 – 15:05
Maciej Mrugala (Mayo Clinic, USA):Strategies to improve anti-cancer drugs delivery across blood-brain barrier
15:05 – 15:25
Edward A. Neuwelt (Oregon Health & Science University, USA): Blood brain barrier disruption therapy in neuro-oncology
15:25 – 15:45
Anuska Andjelkovic-Zochowski (University of Michigan, USA): The blood-brain barrier pathology in stroke – the role of junctional proteins
15:45 – 16:00
David J. Begley (Kings College London, UK): Novel insights into the blood-brain barrier crossing ability of Apo-E and polysorbate-80 modified human serum albumin nanoparticles and their distribution within the CNS: a possible strategy for protein and other therapeutic delivery to the brain
Coffee break 16:00 – 16:15
Session 6. Interactions between the brain barriers and stem cells in the CNS
Chairs: Jaroslaw Aronowski (University of Texas Health Science Center at Houston, USA) and Mehmet Kaya (Koç University School of Medicine, Turkey)
16:15 – 16:35
Isabelle Aubert (Sunnybrook Research Institute & University of Toronto, Canada): Focused ultrasound and the modulation of BBB permeability, glial plasticity and adult neurogenesis
16:35 – 16:55
Simona Parrinello (Imperial College London, MRC London Institute of Medical Sciences, UK): Regulation of neural stem cell quiescence by the vascular niche
16:55 – 17:15
Ursula Wyneken (Universidad de los Andes, Colombia): CNS-periphery crosstalk by small extracellular vesicles
17:15 – 17:35
Salvador Martinez (Neuroscience Institute,University Miguel Hernández – Spanish Council for Scientific Research, Spain): Cellular interactions in the neurovascular unit during brain development
17:35 – 17:55
David Bueno i Torrens (Universitat de Barcelona, Catalunya, Spain): Regulation of embryonic cerebrospinal fluid composition: evolutionary implications for brain development and function
18:00 – 19:30 Poster session
20:00 – 23:00 Gala Dinner (Wesele Restaurant, 10 Main Market Squere)
FRIDAY, September 15, 2017
International Cultural Centre; 25 Main Market Square
09:00 – 09:50 Keynote presentation
Britta Engelhardt (University of Bern, Switzerland):Brain Barriers: The movers and shapers in immune privilege of the CNS
Session 7. Brain barriers and the metabolic axis
Chairs: Matthew Campbell (Trinity College Dublin, Ireland) and Sabita Roy (University of Miami, USA)
09:50 – 10:10 John Kealy(Trinity College Dublin, Ireland): Unifying the neurovascular unit: Neurophysiology, behavior and the blood-brain barrier
10:10 – 10:30 Sabita Roy (University of Miami, USA): Opioid modulation of gut-brain-axis: implications in neurocognitive deficits
Coffee break 10:30 – 10:45
10:45 – 11:05 Stefan Liebner (University Hospital Frankfurt, Germany): Astrocyte-derived Wnts regulate brain vascular permeability in mice affecting BBB maintenance
11:05 – 11:25 Birger Brodin (University of Copenhagen, Denmark): Transport and metabolism of L-glutamate in brain capillary endothelial cells and astrocytes
11:25 – 11:45 Lester Drewes (University of Minnesota, USA): Blood-brain transport pathologies: a growing challenge to the field
11:45 – 12:45 Lunch
Session 8. Behavioral modulations of the blood-brain barrier: diet and exercise
(sponsored by Institute of Animal Reproduction and Food Research of Polish Academy of Science and The Jerzy Kukuczka Academy of Physical Education, Poland)
Chairs: Janina Skipor-Lahuta (Institute of Animal Reproduction and Food Research of Polish Academy of Science, Poland) and Andrzej Malecki (The Jerzy Kukuczka Academy of Physical Education, Poland)
12:45 – 13:05
Yoshichika Kawai(Tokushima University Graduate School, Japan): Accumulation and antioxidative action of dietary flavonoid quercetin in brain
13:05 – 13:25
Zsolt Radak (University of Physical Education, Hungary): The neuroprotective role of physical exercise
13:25 – 13:45
Damian Bailey (University of South Wales, UK): Oxygen, evolution and our radical BBB: pushing the limits with exercise
13:45 – 14:00
Aleksandra Szczepkowska (Institute of Animal Reproduction and Food Research of Polish Academy of Science, Poland): Impact of leptin on choroid plexus response to systemic LPS–induced inflammation in ewes
14:00 – 14:15
Arkadiusz Liśkiewicz (The Jerzy Kukuczka Academy of Physical Education, Poland): Protective impact of exercise on methamphetamine-induced BBB disruption and aberrant neurogenesis in the hippocampus
14:15 – 14:30
Matheus Uba Chupel (University of Coimbra, Portugal): Modulation of blood-brain barrier integrity through anti-inflammatory effect of combined exercise training and taurine supplementation in elderly
14:30 – 14:45 Presentation of the Best Poster Awards (sponsored by IBBS)
14:45 – 15:00 Closing remarks