WEDNESDAY, September 13, 2017


International Cultural Centre; 25 Main Market Square

The registration desk is located at the International Cultural Centre. Registration will start at 10:00. The registration desk will remain open for the duration of the Symposium.

13:00 – 13:15 Welcome

13:15 – 14:05 Keynote presentation

Mikio Furuse (National Institute for Physiological Sciences, Japan): Molecular basis of paracellular diffusion barrier

Session 1. Junctional complexes of the brain barriers – beyond barrier regulation

Chairs: Malgorzata Burek (University of Würzburg, Germany) and Ingolf Blasig (Leibniz-Institut für Molekulare Pharmakologie, Germany)

14:05 – 14:35
Ingolf Blasig (Leibniz-Institut für Molekulare Pharmakologie, Germany): BBB – far more than claudin-5

14:35 – 14:55
Joan Abbott (King’s College London, UK): The BBB PPP – puzzle of the paracellular pathway

Coffee break 14:55 – 15:10

15:10 – 15:30
Eliseo Eugenin (Rutgers Medical School, USA): Novel cellular communication systems in HIV induced neuroinflammation and toxicity

15:30 – 15:50
Malgorzata Burek (University of Würzburg, Germany): Protocadherins at the blood-brain barrier

15:50 – 16:10
Maria Deli (Institute of Biophysics Biological Research Center, Hungarian Academy of Sciences, Hungary): Pericytes and BBB permeability- a co-culture model perspective

16:10 – 16:25
Luca Marchetti (University of Bern, Switzerland): Cellular and molecular mechanisms directing the pathway of Th1 versus Th17 T-cell diapedesis across the blood-brain barrier

16:25 – 16:40
Rainer F. Haseloff (Charité – Universitätsmedizin, Germany): Crossing cellular barriers by a tricellulin-derived peptide

16:40 – 16:55
David A. Antonetti (The University of Michigan, USA): Inhibiting Occludin Ser490 Phosphorylation Prevents Intracerebral Hemorrhage in Stroke

Coffee break 16:55 – 17:15

Session 2. Pathology of the brain barriers – various aspects

Chairs: Hazel Jones (Fluids and Barriers of the CNS; King’s College London, UK) and Aleksandra Szczepkowska (Institute of Animal Reproduction and Food Research of Polish Academy of Science)

17:15 – 17:30
Claus U. Pietrzik (University Medical Center of the Johannes Gutenberg – University Mainz, Germany): Clearance mechanisms of amylogenic proteins across the blood brain barrier

17:30 – 17:45
Fabien Gosselet (University Artois, France): Down-regulation of ABCA7 at the BBB level impacts cholesterol and Aβ peptide exchanges

17:45 – 18:00
Nienke M. de Wit (VU University Medical Center, the Netherlands): Possible different roles for LXRα and LXRβ in regulating blood-brain barrier integrity

18:00 – 18:15
István A. Krizbai (Hungarian Academy of Sciences, Hungary): Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes

18:15 – 18:30
Winfried Neuhaus (Austrian Institute of Technology GmbH, Austria): The blood-brain barrier is altered during Rett Syndrome: Implications for Rett-therapeutics

18:30 – 18:45
Anette H. H. van Boxel-Dezaire (Cleveland Clinic Foundation, USA): IFN-γ, IL-17A, and zonulin can all within 3 hours enhance permeability of the blood-brain and intestinal barrier in vitro; is a similar signal transduction pathway involved in very rapidly opening of these barriers?

18:45 – 19:00
Christina Simoglou Karali (University of Oxford, Oxford, UK): The impact of brain metastasis on endothelial cell function

19:30 – 21:00
Welcome reception (International Cultural Centre; 25 Main Market Squere)


THURSDAY; September 14, 2017


International Cultural Centre; 25 Main Market Square

08:30 – 09:20  Keynote presentation

Michal Schwartz (Weizmann Institute of Science, Israel): Harnessing systemic immunity to combat Alzheimer’s disease

Session 3. Blood-brain barrier and HIV reservoirs in the CNS – formation and eradication

(sponsored by the National Institutes of Health/National Institute of Mental Health; NIH/NIMH)

Chairs: Jeymohan Joseph (NIH/NIMH, USA) and Joan Berman (Albert Einstein College of Medicine, USA)

09:20 – 09:25
Jeymohan Joseph (NIH/NIMH, USA): Opening remarks

09:25 – 09:45
Joan Berman (Albert Einstein College of Medicine, USA): Mechanisms of CNS viral seeding by transmigration of HIV+CD14+CD16+ monocytes across the blood brain barrier: establishment and reseeding of viral reservoirs contributing to HAND

09:45 – 10:05
Kenneth Williams (Boston College, USA): Modulation of perivascular macrophage traffic into and out of the CNS, targeting CNS macrophage reservoirs of HIV

Coffee break 10:05 – 10:20

10:20 – 10:40
Michal Toborek (University of Miami, USA): Regulatory impact of occludin on the formation of HIV reservoirs in neural progenitor cells and brain pericytes

10:40 – 11:00
Carmela Pinnetti (National Institute for the Infectious Disease “L. Spallanzani”, Italy): Blood brain barrier function and the risk of CSF HIV escape

11:00 – 11:20
C. Sabrina Tan (Harvard Medical School, USA): Reaching the CNS with neutralizing antibodies

11:20 – 12:30 Lunch

Session 4. Pathology of the brain barriers – experimental aspects

Chairs: Joan Abbott(King’s College London, UK) and Magdalena Zielińska (Mossakowski Medical Research Centre, Polish Academy of Sciences, Poland)

12:30 – 12:50
Richard F. Keep (University of Michigan, USA): Endogenous mechanisms involved in barrier protection

12:50 – 13:10
Yuri Persidsky (Temple University, USA): Blood brain barrier dysfunction in diabetes mellitus correlates with cognitive deficits

13:10 – 13:30
Shilpa Buch (University of Nebraska Medical Center, USA):A novel role of pericytes in cocaine-mediated neuroinflammation

13:30 – 13:50
Elga de Vries (VU University Medical Center, The Netherlands): Molecular control of the brain barriers in multiple sclerosis

13:50 – 14:10
Martin Lauritzen (University of Copenhagen, Denmark): 2-photon microscopy of cerebral capillaries

Coffee break 14:10 – 14:25

Session 5. Pathology of the brain barriers – clinical aspects  

Chairs: Maciej Mrugala (Mayo Clinic, USA) and Anuska Andjelkovic-Zochowski (University of Michigan, USA)

14:25 – 14:45
Ofer Prager (Ben-Gurion University of the Negev, Israel): Neurovascular interactions under BBB dysfunction

14:45 – 15:05
Maciej Mrugala (Mayo Clinic, USA):Strategies to improve anti-cancer drugs delivery across blood-brain barrier

15:05 – 15:25
Edward A. Neuwelt (Oregon Health & Science University, USA): Blood brain barrier disruption therapy in neuro-oncology

15:25 – 15:45
Anuska Andjelkovic-Zochowski (University of Michigan, USA): The blood-brain barrier pathology in stroke – the role of junctional proteins  

15:45 – 16:00
David J. Begley (Kings College London, UK): Novel insights into the blood-brain barrier crossing ability of Apo-E and polysorbate-80 modified human serum albumin nanoparticles and their distribution within the CNS: a possible strategy for protein and other therapeutic delivery to the brain

Coffee break 16:00 – 16:15

Session 6. Interactions between the brain barriers and stem cells in the CNS  

Chairs: Jaroslaw Aronowski (University of Texas Health Science Center at Houston, USA) and Mehmet Kaya (Koç University School of Medicine, Turkey)

16:15 – 16:35
Isabelle Aubert (Sunnybrook Research Institute & University of Toronto, Canada): Focused ultrasound and the modulation of BBB permeability, glial plasticity and adult neurogenesis

16:35 – 16:55
Simona Parrinello (Imperial College London, MRC London Institute of Medical Sciences, UK): Regulation of neural stem cell quiescence by the vascular niche

16:55 – 17:15
Ursula Wyneken (Universidad de los Andes, Colombia): CNS-periphery crosstalk by small extracellular vesicles

17:15 – 17:35
Salvador Martinez (Neuroscience Institute,University Miguel Hernández – Spanish Council for Scientific Research, Spain): Cellular interactions in the neurovascular unit during brain development

17:35 – 17:55
David Bueno i Torrens (Universitat de Barcelona, Catalunya, Spain): Regulation of embryonic cerebrospinal fluid composition: evolutionary implications for brain development and function

18:00 – 19:30 Poster session

20:00 – 23:00 Gala Dinner (Wesele Restaurant, 10 Main Market Squere)


FRIDAY, September 15, 2017


International Cultural Centre; 25 Main Market Square

09:00 – 09:50 Keynote presentation

Britta Engelhardt (University of Bern, Switzerland):Brain Barriers: The movers and shapers in immune privilege of the CNS

Session 7. Brain barriers and the metabolic axis

Chairs: Matthew Campbell (Trinity College Dublin, Ireland) and Sabita Roy (University of Miami, USA)

09:50 – 10:10 John Kealy(Trinity College Dublin, Ireland): Unifying the neurovascular unit: Neurophysiology, behavior and the blood-brain barrier

10:10 – 10:30 Sabita Roy (University of Miami, USA): Opioid modulation of gut-brain-axis: implications in neurocognitive deficits

Coffee break 10:30 – 10:45

10:45 – 11:05 Stefan Liebner (University Hospital Frankfurt, Germany): Astrocyte-derived Wnts regulate brain vascular permeability in mice affecting BBB maintenance

11:05 – 11:25 Birger Brodin (University of Copenhagen, Denmark): Transport and metabolism of L-glutamate in brain capillary endothelial cells and astrocytes

11:25 – 11:45 Lester Drewes (University of Minnesota, USA): Blood-brain transport pathologies: a growing challenge to the field

11:45 – 12:45 Lunch  

Session 8. Behavioral modulations of the blood-brain barrier: diet and exercise

(sponsored by Institute of Animal Reproduction and Food Research of Polish Academy of Science and The Jerzy Kukuczka Academy of Physical Education, Poland)

Chairs: Janina Skipor-Lahuta (Institute of Animal Reproduction and Food Research of Polish Academy of Science, Poland) and Andrzej Malecki (The Jerzy Kukuczka Academy of Physical Education, Poland)

12:45 – 13:05
Yoshichika Kawai(Tokushima University Graduate School, Japan): Accumulation and antioxidative action of dietary flavonoid quercetin in brain

13:05 – 13:25
Zsolt Radak (University of Physical Education, Hungary): The neuroprotective role of physical exercise

13:25 – 13:45
Damian Bailey (University of South Wales, UK): Oxygen, evolution and our radical BBB: pushing the limits with exercise

13:45 – 14:00
Aleksandra Szczepkowska (Institute of Animal Reproduction and Food Research of Polish Academy of Science, Poland): Impact of leptin on choroid plexus response to systemic LPS–induced inflammation in ewes

14:00 – 14:15
Arkadiusz Liśkiewicz (The Jerzy Kukuczka Academy of Physical Education, Poland): Protective impact of exercise on methamphetamine-induced BBB disruption and aberrant neurogenesis in the hippocampus

14:15 – 14:30
Matheus Uba Chupel (University of Coimbra, Portugal): Modulation of blood-brain barrier integrity through anti-inflammatory effect of combined exercise training and taurine supplementation in elderly

14:30 – 14:45 Presentation of the Best Poster Awards (sponsored by IBBS)

14:45 – 15:00 Closing remarks